Studien Schönheit & Gesundheit

 

Scientific studies collagen hydrolysate (CH)

Study	Journal	Researchers	Type of study	Conclusion
8-Week study on the use of collagen hydrolysate as dietary supplement for skin anti-aging purposes	Rousselot Studies, May 2009	Rousselot	against placebo, double-blind 40 women aged 40 to 59 years old	-26% reduction in micro-furrows; +28% skin hydratation; + 19% skin suppleness; -23% reduction in the depth; -40% width of the wrinkles
Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology.	Skin Pharmacol Physiol 2014;27:47-55 (DOI:10.1159/000351376)	Proksch E. Segger D. Degwert J. Schunck M.Zague V. Oesser S.	Double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group	At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women.

 

Scientific studies/data: Collagen hydrolysate (CH)

Study	Journal	Researchers	Type of study	Conclusion
Resorption and distribution of collagen hydrolysate: Oral administration of C-labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice.	Journal of Nutrition 129. January 1999 p. 1891-1895	Oesser et al. Surgical Research of the Department of General Surgery and Thoracic Surgery of the University of Kiel	Absorption of 14C labeled gelatin hydrolysate was compared to control mice administered 14C labeled proline following intragastric application. Plasma and tissue radioactivity was measured over 192 h.	Ninety-five percent of enterally applied gelatin hydrolysate was absorbed within the first 12 h. The distribution of the labeled gelatin in the various tissues was similar to that of labeled proline with the exception of cartilage, where a pronounced and long-lasting accumulation of gelatin hydrolysate was observed. In cartilage, measured radioactivity was more than twice as high following gelatin administration compared to the control group. These results demonstrate intestinal absorption and cartilage tissue accumulation of gelatin hydrolysate and suggest a potential mechanism for previously observed clinical benefits of orally administered gelatin.

 

Scientific studies/data: Collagen hydrolysate (CH)

Study	Journal	Researchers	Type of study	Conclusion
Therapy of osteoarthritis: What effect have gelatine products?	Therapiewoche 41 Heft 38. 1991 Pp 2456-2461	Adam M	Randomized, double-blind Cross-Over-Study over four months, 81 patients	Patients with osteoarthritis in knee or hip received 10g of collagen hydrolysate  over a period of two months (plus 2 months wash-out period). CH showed a significant reduction of pain in the patient population.
Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats	Journal of Agric Food Chem 2010 Jan 27; 58(2): 835-41	Watanabe-Kamiyama et al.	Radioactive  low molecular weight collagen hydrolysate (LMW-CH) administered to rats	Findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone. LMW-CH was absorbed into the blood of rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and was increased in the femur.
Role of collagen hydrolysate in bone and joint disease.	Seminars in arthritis and rheumatism Vol 30, No 2 (Oct) 2000 pp87-99	Moskowitz RW et al.	Multicenttered (USA, UK, Deutschland), randomised, double blind,  placebo controlled study. 389 Patients with Gonarthrosis, 10g CH daily intake during 24 weeks and 8 weeks wash-out)	Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders. The German study showed significant results on pain reduction and improved function over placebo. In the USA and UK no significant difference was reported, however they experienced a much higher drop-out  rates: USA 42%, UK 37% compared to Germany 7%. The authors explains this due to different habits in taking pain killers, study condition,s and nutrional habits. CH has a unpleasant taste.

 

Scientific studies/data: Collagen hydrolysate (CH)

Study	Journal	Researchers	Type of study	Conclusion
Effect of collagen hydrolysate in articular pain	Complementary Therapies in Medicine, Volume 20, Issue 3, June 2012, 124130	O. Bruyère, B. Zegels, L. Leonori, V. Rabenda, A. Janssen, C. Bourges, J.-Y. Reginster	Randomized, double-blind, placebo controlled, 6 months 200 patients	Study results suggest that collagen hydrolysate 1200 mg/day could increase the number of clinical responders (i.e. improvement of at least 20% on the VAS) compared to placebo.
Aenderung der Gewebeeigenschaften durch CH-Einnahme . Eine biomechanische in-vivo Pilotstudie	Extracta orthopaedica 4 2001 Pp 12-15	Weh L, Petau C	Biomechanische Charakteristika der Fingerkapseln (computergesteuer-tes Fingerhyper-extensometer.	24 Personen nahmen über 6 Monaten jeweils 10g KH. Die Resultate zeigen eine verminderte Integralfläche der Kraft/Winkel-Regressionskurve (p˂0,001), was auf eine erhöhte Gewebefestigkeit zurückzuführen ist.
24-Week study on the use of collagen hydrolysate as dietary supplement in athletes with activity-related joint pain.	Current Medical Research and Opinion. 2008 May;24(5):1485-96.	Clark KL et al.	Randomized, placebo-controlled, double-blind study 147 patients	The results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group. Despite the study’s size and limitations, the results suggest that athletes consuming collagen hydrolysate can reduce parameters (such as pain) that have a negative impact on athletic performance.

 

Scientific data Calcium

Molecule	Information
Calcium *1	Calcium is essential for living organisms, in particular in cell physiology, where movement of the calcium ion into and out of the cytoplasm functions as a signal for many cellular processes. As a major material used in mineralization of bone, teeth and shells, calcium is the most abundant metal by mass in many animals. Calcium supplements are used to prevent and to treat calcium deficiencies. It is recommended to spread doses throughout the day. Calcium in Food Nieca Goldberg, MD, medical director of the Women’s Heart Program at NYU Langone Medical Center in New York, says women must be aware of how much calcium they get through diet and how much they get through supplements to avoid getting too much of this mineral. “Calculate how much you are eating through food and balance off the rest with supplements so it equals 1,200 milligrams of calcium a day for women older than 50,” she says.
Calcium *2	Voir le PDF Swissmilk pour les teneurs en calcium: Une dose se situe entre 200 et 250 mg ( 1 dose journalière ExtraCellWoman : 240mg) 1 verre de lait de 2 dl : 240mg de calcium 1 yogurt nature de 180 g: 120 mg de calcium 50g de mozarella : 450 mg de calcium 40g d’Emmental ou autre fromage à pâte dure : 600 mg de calcium Source : Swissmilk

 

Scientific studies/data: Calcium

Study	Journal	Researchers	Type of study	Conclusion
Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis	British Medical Journal BMJ 2011;342:d2040	Mark J Bolland et al.	Objectives To investigate the effects of personal calcium supplement use on cardiovascular risk in the Women’s Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study), using the WHI dataset, and to update the recent meta-analysis of calcium supplements and cardiovascular risk. Design Reanalysis of WHI CaD Study limited access dataset and incorporation in meta-analysis with eight other studies.	Conclusions Calcium supplements with or without vitamin D modestly increase the risk of cardiovascular events, especially myocardial infarction, a finding obscured in the WHI CaD Study by the widespread use of personal calcium supplements. A reassessment of the role of calcium supplements in osteoporosis management is warranted.

 

Scientific data Magnesium & minerals *

Molecule	Information
Magnesium	Magnesium is the eleventh most abundant element by mass in the human body. Its ions are essential to all cells. They interact with polyphosphate compounds such as ATP, DNA, and RNA. Hundreds of enzymes require magnesium ions to function. Symptoms of magnesium deficiency include hyperexcitability, muscular symptoms (cramps, tremor,  spasms, weakness), fatigue, loss of appetite, apathy, confusion, insomnia, irritability, poor memory, and reduced ability to learn. Moderate to severe magnesium deficiency can cause tingling or numbness, heart changes, rapid heartbeat, continued muscle contractions, nausea, vomiting. Magnesium in food: Dark leafy greens, nuts, seeds, fish, beans, whole grains, avocados, yogurt, bananas, dried fruit, dark chocolate.
Copper, manganese, chrome Help protect cells against oxydative stress	Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms). In humans, copper is essential to the proper functioning of organs and metabolic processes. The human body has complex homeostatic mechanisms which attempt to ensure a constant supply of available copper, while eliminating excess copper whenever this occurs. Copper is incorporated into a variety of proteins and metalloenzymes which perform essential metabolic functions; the micronutrient is necessary for the proper growth, development, and maintenance of bone, connective tissue, brain, heart, and many other body organs. Copper is involved in the formation of red blood cells, the absorption and utilization of iron, the metabolism of cholesterol and glucose, and the synthesis and release of life-sustaining proteins and enzymes. These enzymes in turn produce cellular energy and regulate nerve transmission, blood clotting, and oxygen transport. Copper stimulates the immune system to fight infections, to repair injured tissues, and to promote healing. Copper also helps to neutralize “free-radicals”, which can cause severe damage to cells

 

Scientific data minerals manganese & chrome

Molecule	Information
Manganese	Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system
Chrome	Chromium is now generally recognized to play an important role in glucose and lipid metabolism. Chromium supplementation has the effect of normalizing blood sugar levels

 

Scientific studies – glucosamine & PG
(PG: Proteoglycans)

Study	Journal	Researchers	Type of study	Conclusion
Glucosamine supplementation extends life span of nematodes and of ageing mice.	Nature Communications, 2014 – ETH Zürich  April 2014	Sandra Weimer et al	The mice were 100 weeks of age, reflecting a comparative human age of approximately 65 years. A control group of mice received no glucosamine while otherwise receiving an identical diet. Feeding the supplement to mice extended their lifespan by almost 10%, reflecting around 8 additional years of human lifespan. Moreover, glucosamine improved glucose metabolism in elderly mice indicating protection from diabetes, a life-threatening disease most prevalent amongst the elderly.	Glucosamine promotes longevity by mimicking low-carb diet, study finds ( on mice)
Age-related changes in the proteoglycans of human skin.	Arch Biochem Biophys. 2000 Jan 1;373(1):91-101.	Carrino DA Sorrell JM, Caplan AI.	Department of Biology, Case Western Reserve University, Cleveland, Ohio, 44106-7080, USA. dac5@po.cwru.edu	The observation that proteoglycans in skin show dramatic age-related differences suggests that these changes may be involved in the age-related changes in the physical properties of skin.

 

Scientific studies/data: glucosamine sulfate

Study	Journal	Researchers	Type of study	Conclusion
Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.	Menopause. 2004 Mar-Apr;11(2):138-43.	Bruyere O at al.	Preplanned combination of two three-year, randomized, placebo-controlled,  studies evaluating the effect of glucosamine sulfate on symptoms and structure modification in OA. 318 women	This analysis, focusing on a large cohort of postmenopausal women, demonstrated for the first time that a pharmacological intervention for OA has a disease-modifying effect in this particular population, the most frequently affected by knee OA.

 

Scientific studies/data: glucosamine sulfate (GS)

Study	Journal	Researchers	Type of study	Conclusion
Glucosamine Sulfate Prevents Total Joint Replacement In The Long-Term Follow-Up Of Knee Osteoarthritis Patients	Arthritis Rheum. 2004: 50, 9 (suppl): 251	Karel Pavelka et al	To assess the incidence of joint replacement after a further long-term follow-up. Patients of two recent randomised, placebo controlled, double-blind, 3-year clinical trials in knee osteoarthritis (OA) , with GS. 136 patients	Treatment for up to 3 years with glucosamine sulphate in knee OA prevented total joint replacement during a further follow-up of 5 years after drug withdrawal, probably because of the effect on joint structure achieved during treatment.14 out of 136 had knee replacement: 11/67 who had been on placebo (16.4%) 3/69 who had been on GS (4.3%)
Glucosamine sulfate in the treatment of knee osteoarthritis symptoms	Arthritis & Rheumatism Volume 56, Issue 2, pages 555–567, February 2007	Gabriel Herrero-Beaumont et al.	318 patients randomized, placebo controlled, double-blind trial in which acetaminophen, the currently preferred medication for symptomatic treatment of OA, was used as a side comparator.	To date, no studies have demonstrated any other pharmacologic treatment to have the same efficacy as glucosamine sulfate for the long-term treatment of OA symptoms. The efficacy results obtained with glucosamine sulfate were significant and clinically relevant in the present study in which acetaminophen, the currently recommended preferred medication (2, 3), was used as a side comparator.

 

Scientific studies glucosamine sulfate

Study	Journal	Researchers	Type of study	Conclusion
Sulfate could mediate the therapeutic effect of glucosamine sulfate	Lady Davis Institute for Medical Research and Division of Rheumatology, Sir Mortimer B. Jewish General Hospital, Montreal, Quebec, Canada.	Hoffer LJ, Kaplan LN, Hamadeh MJ, Grigoriu AC, Baron M.	Sulfate is required for glycosaminoglycan synthesis. we tested whether oral glucosamine sulfate increases serum sulfate concentrations and whether the sulfate concentration in the synovial fluid reflects that in the serum. The serum sulfate concentration of 7 normal subjects was 331 +/- 21 micromol/L before ingestion of 1.0 g glucosamine sulfate and 375 +/- 17 micromol/L 3 hours after (P <.05). Serum sulfate concentrations decreased from 325 +/- 19 to 290 +/- 19 micromol/L when the same dose of glucosamine sulfate was ingested with 1.0 g of the analgesic drug acetaminophen, which is largely metabolized by sulfation (P <.05). Synovial fluid and serum sulfate concentrations were closely similar when measured in 15 patients undergoing diagnostic needle aspiration of a knee effusion (r =.99, slope =.97, P <.0001).	These results do not prove that glucosamine sulfate improves osteoarthritis, but considered with other data, they do provide a plausible biochemical mechanism for its reported beneficial effects. This hypothesis is clinically relevant because it predicts that nonsulfate salts of glucosamine will be ineffective and that renal function, diet, and concurrent acetaminophen therapy could confound clinical trials of this therapy

 

Scientific studies/data: rose hip (RHP)
(Hagebutte – cynorrhodon)

Study	Journal	Researchers	Type of study	Conclusion
A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects	Mediators of Inflammation Volume 2014, Article ID 105710, 10 pages	Joseph Schwager, Nathalie Richard, Rotraut Schoop, and SwenWolfram	In vitro cell cultures with RHP extracts.	Rose hip powder (RHP) alleviates osteoarthritis (OA) due to its anti-inflammatory and cartilage-protective properties. Substances contained in RHP might contribute to its clinical efficacy. The activity of two RHP (i.e., RH-A, from the whole fruit, RH-B, from fruits without seeds) was investigated in human peripheral blood leukocytes (PBL) and primary chondrocytes (NHAC-kn). RH-A and RH-B diminished the secretion of chemokines and cytokines in LPS/IFN-

 

Scientific studies/data: rose hip (RHP)

Study	Journal	Researchers	Type of study	Conclusion
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.	BMC Complement Altern. Med. 2011 Nov 3;11:105. doi: 10.1186/1472-6882-11-105	Schwager J.	Cellular systems (macrophages, peripheral blood leukocytes and chondrocytes), which respond to inflammatory and OA-inducing stimuli, are used as in vitro surrogates to evaluate the possible pain-relief and disease-modifying effects of RHP.	Clinical studies have shown that rose hip powder (RHP) alleviates osteoarthritis (OA). This might be due to anti-inflammatory and cartilage-protective properties of the complete RHP or specific constituents of RHP. RHP and GLGPG (Galakto-Lipids) attenuate inflammatory responses in different cellular systems (macrophages, PBLs and chondrocytes). The effects on cytokine production and MMP expression indicate that RHP and its constituent GLGPG down-regulate catabolic processes associated with osteoarthritis (OA) or rheumatoid arthritis (RA). These data provide a molecular and biochemical basis for cartilage protection provided by RHP.
A powder made from seeds and shells of a rose‐hip subspecies (Rosa canina-cynorrhodon) reduces symptoms of knee and hip osteoarthritis	Osteoarthritis and Cartilage (2008), 16, Supplement 1, S8–S9	K. Winther et al.	Randomized, double-blind, placebo-controlled, 94 patients with OA	The data suggest that the present herbal remedy can alleviate symptoms of osteoarthritis and reduce the consumption of ‘rescue medication’.

 

Scientific studies/data: antioxidants gentian, edelweiss, extramel®

Study	Journal	Researchers	Type of study	Conclusion
Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance	Department of Agronomy, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia.	A Kusšar et al.	Electron spin resonance (ESR) spectrometry	This study proves that yellow gentian leaves and roots exhibit considerable antioxidant properties, expressed either by their capability to scavenge DPPH or superoxide radicals.
In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models	Journal of Ethnopharmacology	Ester Speroni et al	Extracts of the aerial parts and roots of Edelweiss were investigated for their anti-inflammatory and analgesic effects after oral administration.	Histological evaluation of the treated paws showed a significant reduction of the inflammatory response in the pre-treated specimens.
Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?	Arthritis Rheum. 1996 Apr; 39(4):648-56.	McAlindon TE et al.	Participants in the Framingham Osteoarthritis Cohort Study underwent knee evaluations by radiography. 640 patients.	High intake of antioxidant micronutrients, especially vitamin C, may reduce the risk of cartilage loss and disease progression in people with OA.

 

Scientific studies/data: antioxidants

Study	Journal	Researchers	Type of study	Conclusion
The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study	Journal of Dermatological Treatment, 2001, Vol. 12, No. 1 , Pages 47-51	H Murad and Michael P Tabibian	A randomized, controlled, single-blind study was conducted with 53 female volunteers who were supplied with an oral supplement containing glucosamine, amino acids, minerals, and various antioxidant compounds.	The use of an oral supplement containing glucosamine, minerals, and various antioxidant compounds can potentially improve the appearance of visible wrinkles and fine lines. It does not, however, affect epidermal hydration.
Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel®) on stress and fatigue in healthy people	Nutrition Journal	Marie-Anne Milesi et al.	Double-blind. Placebo controlled 70 healthy participants	This pilot study showed that an oral supplementation with a proprietary melon juice concentrate rich in SOD may have a positive effect on several signs and symptoms of perceived stress and fatigue
Pharmacokinetics of superoxide dismutase in rats after oral administration	Biopharmaceutics & Drug disposition, Volume 17, issue 2, pages 165–174, March 1996	C. Regnault,  M. Soursac, M. Roch-Arveiller, E. Postaire, G. Hazebroucq	The kinetic behaviour of  erythrocyte Cu–Zn SOD was investigated in rats after subcutaneous and oral administrations of doses . The maximum concentration (Cmax) in blood cell pellets ranged from 8·65 to 11·03 U/mg haemoglobin (Hb) after subcutaneous injection, and from 4·48 to 8·23 U/mg Hb after oral administration. The maximum concentrations were reached in 5 h (tmax) for the two routes.	The maximum bioavailability after oral administration was 14% for free SOD, 22% for SOD encapsulated into liposomes, and 57% when ceramides were added to liposomes Researchers believe that SOD decreases with aging and evidence suggests that boosting falling SOD levels may help guard against disease and extend life span.

 

 Scientific data amino acids & vitamins

Molecule	Information
L-lysin	Amino acid: L-Lysine is a necessary building block for all protein in the body. L-Lysine plays a major role in calcium absorption; building muscle protein; recovering from surgery or sports injuries; and the body’s production of hormones, enzymes, and antibodies.
L-threonin	Amino acid: L-threonine is a key component of collagen, elastin and enamel (teeth) proteins
Vit C	Ascorbic acid or vitamin C is a common enzymatic cofactor in mammals used in the synthesis of collagen. Ascorbate is a powerful reducing agent capable of rapidly scavenging a number of reactive oxygen species (ROS). Moderately higher blood levels of vitamin C measured in healthy persons have been found to be prospectively correlated with decreased risk of cardiovascular disease and ischaemic heart disease, and an increase life expectancy.
Vit D	Vitamin D is a group of fat-soluble secosteroids responsible for intestinal absorption of calcium and phosphate
Vit E	As a fat-soluble antioxidant, it stops the production of reactive oxygen species formed when fat undergoes oxidation

 

 Scientific data vitamin B-complex & vit K

Molecule	Information
Vitamin B complex	B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism. Contribute to reduce fatigue. Contribute to normal function of nervous system. Vitamin B1 (thiamine) Vitamin B2  (riboflavin) Vitamin B3 (niacin) Vitamin B5 (pantothenic acid) Vitamin B6 (pyridoxine) Vitamin B7 (biotin) Vitamin B9 (folic acid) Vitamin B12 (cyanocobalamin)
Choline	Choline is a water-soluble essential nutrient. It is usually grouped within the B-complex vitamins. Choline must be consumed through the diet for the body to remain healthy. It is used in the synthesis of the constructional components in the body’s cell membranes. The 2005 National Health and Nutrition Examination Survey (USA)  stated that only 2% of postmenopausal women consume the recommended intake for choline. Choline in food: Srimps, eggs, scallops, chicken, tuna, salmon, beef, collard greens (legumes verts feuillus – dunkelgrünen Blattgemüsen)
Vit K	Vitamin K refers to a group of structurally similar, fat-soluble vitamins the human body needs for complete synthesis of certain proteins that are required for blood coagulation, and also certain proteins that the body uses to manipulate binding of calcium in bone and other tissues. The vitamin K-related modification of the proteins allows them to bind calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Low levels of vitamin K also weaken bones and promote calcification of arteries and other soft tissues.

Source : wikipedia

 

 Scientific data: green tea, millet, , Q10,

Molecule	Information
Green tea	Green tea contains a variety of enzymes, amino acids, carbohydrates, lipids, sterols, related compounds, phytochemicals, and dietary minerals. Numerous claims have been made for the health benefits of green tea based on its chemical composition, in vitro studies, and animal studies. Preliminary research on many of these claims is promising, but many also require further study to evaluate.
Millet / Hirse	Millets are rich in B vitamins (especially niacin, B6 and folic acid), fluor, phosphor, calcium, iron, potassium, magnesium, zinc and alot of silice. Millet grain phenolics and their role in disease risk reduction and health promotion: A review Elsevier journal of functional food (doi:10.1016/j.jff.2013.02.004), by Fereidoon Shahidi … Millet grain phenolics are bioaccessible, possess bioactivities against several pathophysiological conditions and may serve as potential natural sources of antioxidants in food and biological systems. While this review also shows the existence of a substantial body of evidence for in vitro antioxidant activity of millet grain phenolics, there is a clear gap for in vivo information. However, the use of millets, as nutraceuticals and specialty foods in disease risk reduction and overall health and wellness is warranted.
Q10	This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney—have the highest CoQ10 concentrations. Supplementation of CoQ10 has been found to have a beneficial effect on the condition of some sufferers of migraine. This is based on the theory that migraines are a mitochondrial disorder, and that mitochondrial dysfunction can be improved with coenzyme Q10. The Canadian Headache Society guideline for migraine prophylaxis recommends, based on low-quality evidence, that 300 mg of CoQ10 be offered as a choice for prophylaxis.

 

Scientific studies/data: betaglucans

Study	Journal	Researchers	Type of study	Conclusion
Cholesterol-lowering effects of oat β-glucan	Nutr Rev.  2011 Jun;69(6):299-309	Othman RA, Moghadasian MH, Jones PJ	The present review aims to investigate if results from more recent studies are consistent with the original conclusions reached by the FDA and JHCI	Results of this analysis show that studies conducted during the past 13 years support the suggestion that intake of oat β-glucan at daily doses of at least 3 g may reduce plasma total and low-density lipoprotein (LDL) cholesterol levels by 5-10% in normocholesterolemic or hypercholesterolemic subjects. Studies described herein have shown that, on average, oat consumption is associated with 5% and 7% reductions in total and LDL cholesterol levels, respectivelySignificant scientific agreement continues to support a relationship between oat β-glucan and blood cholesterol levels, with newer data being consistent with earlier conclusions made by the FDA and JHCI.

 

 Scientific data: beta glucans, guar, agar-agar, steviol, acide silicique

Molecule	Information
Guar	Guar gum has been considered of interest in regard to both weight loss and diabetic diets. It is a thermogenic substance. Moreover, its low digestibility lends its use in recipes as a filler, which can help to provide satiety, or slow the digestion of a meal, thus lowering the glycemic index of that meal. Efsa: guar gum helps to maintain healthy cholesterol levels – guar gum helps to maintain healthy levels of blood lipids , with 10g of guar per helping.
Agar-agar	Agar-agar is a jelly-like substance, obtained from algae, it canbe used as an appetite suppressant
Steviol	Steviol glycosides are the chemical compounds responsible for the sweet taste of the leaves of the South American plant Stevia rebaudiana. Steviol glycosides from Stevia rebaudiana have been reported to be between 30 and 320 times sweeter than sucrose. Additionally, they do not induce a glycemic response when ingested,
Acide silicique	Continuing research of the correlation of aluminium and Alzheimer’s disease has in the last few years included the use of silicic acid in beverages, due to its abilities to both reduce aluminium uptake in the digestive system as well as cause renal excretion of aluminium. Study has shown that physiological concentration of orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Choline-stabilized orthosilicic acid is a bioavailable nutritional supplement. It has been shown to prevent the loss of hair tensile strength, have positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails,abate brittle nail syndrome, partially prevent femoral bone loss in the aged ovariectomized rat model, increase collagen concentration in calves , and have potential beneficial effect on bone collagen formation in osteopenic females.